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Carnitine palmitoyltransferase-1 up-regulation by PPAR-/ prevents lipid-induced endothelial dysfunction

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There is a theoretical risk of accelerated growth of pre-existing cancers, as IGF-1 is a growth factor [1]

In multiple myeloma, CB-839 as a single agent was not efficient, but the main purpose of the research was the discovery of the mechanisms that help to overcome resistance to carfilzomib